COMPOSITION
Each capsule contains:
- Calcium Dobesilate 500 mg.
CLINICAL PHARMACOLOGY
Calcium Dobesilate reduces capillary permeability and improves venous tone. It inhibits platelet aggregation and reduces blood viscosity. It also enhances nitric oxide synthesis, improving endothelium-dependent relaxation.
INDICATIONS AND USAGE
Used for the treatment of chronic venous insufficiency, hemorrhoidal attacks, diabetic retinopathy, and varicose vein complications.
CONTRAINDICATIONS
Hypersensitivity to calcium dobesilate or any excipients. Severe renal impairment.
PRECAUTIONS
Monitor in patients with known bleeding disorders. Caution in pregnancy and renal dysfunction. Avoid in those with sulfonamide allergy.
DRUG INTERACTIONS
May potentiate the effects of anticoagulants. Monitor INR if used concomitantly.
PREGNANCY & LACTATION
Use only if clearly needed. Caution during lactation as safety data is limited.
DOSAGE AND ADMINISTRATION
500 mg twice daily or as directed by a physician.
ADVERSE REACTIONS
Rash, gastrointestinal discomfort, fever, and rare cases of agranulocytosis.