PROZPRA DSR

- Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion by inhibiting the H+/K+ ATPase in the gastric parietal cells.
- Domperidone is a dopamine D2 receptor antagonist that enhances gastrointestinal motility and controls nausea and vomiting.

Indicated for the treatment of:
- Gastroesophageal Reflux Disease (GERD)
- Gastric and peptic ulcers
- Reflux esophagitis
- Dyspepsia
- Regurgitation

Contraindicated in patients with:
- Known hypersensitivity to pantoprazole, domperidone, or any component of the formulation
- Prolactinoma
- Gastrointestinal hemorrhage, obstruction or perforation

Use with caution in patients with:
- Hepatic or renal impairment
- Risk of QT prolongation
- Electrolyte imbalance

Pantoprazole may reduce the absorption of drugs that require gastric pH.
Domperidone may interact with drugs that prolong QT interval or inhibit CYP3A4.

Use only if clearly needed during pregnancy.
Domperidone is excreted in breast milk; caution advised for lactating women.

One capsule once daily before breakfast or as directed by a physician.

- Pantoprazole: Headache, diarrhea, nausea, abdominal pain.
- Domperidone: Dry mouth, dizziness, QT prolongation (rare).